News Release Details

BOSTON, April 13, 2023 (GLOBE NEWSWIRE) -- Galecto, Inc. (NASDAQ: GLTO), a clinical-stage biotechnology company and world leader in galectin biology focused on the development of novel treatments for fibrosis and cancer, today announced it will present two posters at the upcoming American Association for Cancer Research (AACR) Annual Meeting 2023, taking place April 14-19 in Orlando, Florida.

Galecto is currently conducting a Phase 2a trial of GB1211, a small molecule galectin-3 inhibitor, in combination with atezolizumab for the first-line treatment of non-small cell lung cancer (NSCLC). Many tumors overexpress galectin-3, which is linked to several cancer promoting mechanisms, including those linked to checkpoint inhibitor and chemotherapy resistance, and may ultimately lead to worse clinical outcomes. Several other forms of galectins, such as galectin-1, are also associated with cancer. The data to be presented at AACR suggests that both selective inhibition of galectin-1 and dual inhibition of galectin-1 and galectin-3 could provide potential cancer therapies, either alone or combination with immune checkpoint inhibitors, to boost immune infiltration and/or activation in the tumor microenvironment of lung adenocarcinoma, pancreatic cancer and other aggressive cancers.

“We are very pleased to be presenting this data at AACR as it demonstrates the potential anti-cancer effects of both our galectin-1 specific inhibitor and our dual acting galectin-1/3 inhibitor,” said Hans Schambye, M.D., Ph.D., President and Chief Executive Officer of Galecto. “This shows the depth of our pipeline and our ability to continuously develop novel molecules that may provide further tools in the fight against cancer.”

Details for the poster presentations are as follows:

Abstract LB104
Title: Preclinical evaluation of the role of Galectin-1 in tumor immune evasion associated mechanisms using highly selective Galectin-1 small molecule inhibitor
Session: Late-Breaking Research: Immunology 1
Date: Monday, April 17, 2023
Time: 9:00 am – 12:00 pm ET
Location: Poster Section 35
Poster Number: 20

Abstract LB173
Title: A bioinformatics approach to determine the potential benefit of blocking both Galectin-1 and Galectin-3 in cancer
Session Title: Late-Breaking Research: Bioinformatics, Computational Biology, Systems Biology, and Convergent Science 2
Date: Tuesday, April 18, 2023
Time: 9:00 am – 12:30 pm ET
Location: Poster Section 34
Poster Board Number: 6

Following presentation at the AACR Annual Meeting, these posters will be available on the Scientific Conferences page of Galecto’s investor relations website at https://ir.galecto.com/news-and-events/scientific-events.

About Galecto
Galecto is a clinical stage company incorporated in the U.S. that is developing small molecule-based inhibitors of galectin-3 and LOXL2. Galecto has multiple ongoing Phase 2 clinical programs in fibrosis and cancer, including (i) an inhaled galectin-3 modulator (GB0139) in a Phase 2b trial for the treatment of idiopathic pulmonary fibrosis; (ii) an orally active LOXL2 inhibitor (GB2064) in a Phase 2a trial for the treatment of myelofibrosis; (iii) an orally active galectin-3 inhibitor (GB1211) in a recently completed Phase 1b/2a trial in liver cirrhosis; and (iv) an orally active galectin-3 inhibitor (GB1211) in combination with atezolizumab (Tecentriq®) in a separate Phase 2 trial for the treatment of non-small cell lung cancer.

Galecto intends to use its website as a means of disclosing material non-public information. For regular updates about Galecto, visit www.galecto.com.

Forward-Looking Statements
Certain statements in this press release are forward-looking statements that involve a number of risks and uncertainties. Such forward-looking statements include statements about Galecto’s ability to make progress across its clinical pipeline of assets and the potential efficacy of Galecto’s galectin-1 and galectin-3 inhibitor product candidates. The words “may,” “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “target” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. For such statements, Galecto claims the protection of the Private Securities Litigation Reform Act of 1995. Actual events or results may differ materially from Galecto's expectations. Factors that could cause actual results to differ materially from the forward-looking statements include risks and uncertainties related to the development of Galecto’s product candidates and their therapeutic potential, having adequate funds and their use, and those disclosed in Galecto’s filings with the Securities and Exchange Commission (SEC), including, but not limited to, Galecto’s Annual Report on Form 10-K, as filed with the SEC on March 9, 2023. These forward-looking statements represent Galecto's judgment as of the time of this release. Galecto disclaims any intent or obligation to update these forward-looking statements, other than as may be required under applicable law.

Source: Galecto, Inc.